Fibromyalgia — chronic pain treatment

What is fibromyalgia

Fibromyalgia is a chronic condition characterized by widespread musculoskeletal pain, severe fatigue, sleep disturbances, and cognitive disorders (“fibro fog”). It affects 2–4% of the population, predominantly women aged 30—60. This is not “psychosomatic” — it is a real neurobiological condition with proven changes in pain processing.

Central sensitization

The main mechanism — amplification of pain signals in the CNS. The brain “turns up the volume” on normal body signals, converting normal pressure into pain (allodynia). Pain threshold is lowered.

Peripheral pain generators

Trigger points in muscles and fascia, micro-inflammation in small joints, compression of small nerve fibers — constantly feed central sensitization. These are whwith regenerative methods® targets.

Neuroendocrine disturbances

Decreased serotonin, norepinephrine, disruption of the hypothalamic-pituitary-adrenal axis. Explains accompanying symptoms: depression, anxiety, sleep disturbance, irritable bowel syndrome.

Genetics & triggers

Genetic predisposition (COMT, 5-HT2A polymorphisms) + trigger: trauma, infection, stress, surgery. Family history increases risk 8-fold. The condition is not “imagined” — it has a biological basis.

Symptoms & diagnosis

Widespread pain

Pain “everywhere” — in muscles, joints, back, neck, chest. Migrating, worsens with stress, cold, sleep deprivation. Duration >3 months. Often described as “burning,” “aching,” “tightness.”

Fatigue & sleep disturbance

Severe fatigue not relieved by rest. Non-restorative sleep — patient wakes “broken.” Disruption of deep sleep phase (alpha-delta anomaly on EEG).

Cognitive impairment (“fibro fog”)

Decreased concentration, forgetfulness, difficulty finding words. Not dementia — reversible with pain and sleep control. But seriously affects work capacity and quality of life.

Diagnostic criteria (ACR 2016)

Widespread Pain Index (WPI) ≥7 + Symptom Severity Scale (SSS) ≥5. Symptoms >3 months. No other condition explaining the pain. Blood tests, MRI, X-ray — normal (diagnosis of exclusion).

Why standard treatment is insufficient

Antidepressants (duloxetine, amitriptyline)

Act on descending pain inhibitory pathways. Effective in 30–50% of patients. Side effects: drowsiness, weight gain, sexual dysfunction. Do not eliminate peripheral pain sources.

Pregabalin / Gabapentin

Reduce neuronal excitability. Moderate pain effect (30% reduction in 40% of patients). Side effects: dizziness, edema, cognitive worsening. Dependence with long-term use.

NSAIDs & analgesics

Virtually ineffective in fibromyalgia — pain is not inflammatory in the classical sense. Opioids are contraindicated: they worsen central sensitization. Paracetamol — placebo effect.

What the standard approach misses

All medications target the CNS but ignore peripheral pain generators: trigger points, fascial adhesions, small joint dysfunction. Regenerative treatment fills this gap.

Fibromyalgia treatment with regenerative methods

Regenerative treatment does not replace baseline therapy but complements it by eliminating peripheral pain sources. The principle — “switch off the generators” so central sensitization can subside.

CGF into trigger points

Concentrated growth factor injections into main pain zones (trapezius, paravertebral muscles, gluteal, piriformis). Eliminate local ischemia and micro-inflammation. 5–8 points per session.

Perineural injections (PNI)

CGF micro-injections around superficial nerves in allodynia zones. Restore nerve microenvironment, reduce ectopic activity. Especially effective for burning pain.

Facet & SI joints

For concurrent back pain — targeted PRP/CGF injections into facet joints and sacroiliac joint under ultrasound guidance. Eliminate one of the “generators.”

Combined protocol

3—5 sessions at 3—6-week intervals. Each session targets 2—3 most painful zones. Maintenance procedure — every 6–12 months. Compatible with all baseline medications.

Results & prognosis

Regenerative treatment for fibromyalgia is not a panacea but a significant complement to standard therapy. Greatest effect — in patients with pronounced peripheral pain component (multiple trigger points, specific joint pain).

40–60%Pain reduction (VAS)

65%Reduce medication dose

3—5Sessions per course

6–12 moEffect duration

Clinic and method matching — free of charge

Describe your case and attach your MRI report. We will identify clinics that use the relevant methods and forward your request to them. No obligation; we reply within two working days.

Send a request

Frequently asked questions

Can fibromyalgia be completely cured?

Complete cure is not yet possible. But regenerative treatment reduces pain by 40–60% and improves quality of life by targeting peripheral pain generators.

How does regenerative treatment differ from standard treatment?

Standard therapy targets the CNS. Regenerative treatment eliminates peripheral pain sources — trigger points, fascial adhesions, micro-inflammation in joints.

How many procedures are needed?

3—5 sessions at 3—6-week intervals. Maintenance procedure every 6–12 months.

Are there contraindications?

Active infection, oncology. The autoimmune component of fibromyalgia is NOT a contraindication — the patient’s own cells are used.

Do I need to stop current medications?

No. Regenerative treatment is compatible with antidepressants, pregabalin, and NSAIDs. The goal is gradual dose reduction as pain decreases.