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Detailed comparisons
Patients often face a choice: surgery, injections, pills, or regenerative therapy? We have prepared detailed comparisons based on evidence-based medicine — without advertising slogans. Each article contains the mechanism of action, indications, contraindications, recovery time, cost, and PubMed research data.
Regenerative treatment vs Surgery
When surgery can be avoided, and when it is mandatory. Objective comparison of indications.
Read comparison →Regenerative treatment vs Joint Replacement
Regeneration vs joint replacement. Regenerative treatment provides complete tissue regeneration with a lifelong effect.
Read comparison →PRP vs Hyaluronic Acid
Mechanisms, efficacy, duration. Why regenerative treatment outperforms both.
Read comparison →Stem Cells vs PRP
Difference between PRP, CGF, MFAT, BMAC. When stimulation is enough vs when regeneration is needed.
Read comparison →Conservative vs Surgical
Treatment pyramid from pills to surgery. Where regenerative treatment fits in this hierarchy.
Read comparison →Comparison matrix: surgery vs PRP vs regenerative treatment
Key parameters of the three main approaches to treating osteoarthritis, tendinopathies, and degenerative spinal conditions. Standard PRP is presented as the baseline regenerative procedure, regenerative methods — as the advanced comprehensive protocol.
Key differences of regenerative treatment
From surgery
No general anesthesia, no incisions, no hospitalization. Recovery in days, not months. At the same time, in severe cases (complete ligament tears, unstable fractures, stage IV arthrosis with deformity) surgery remains necessary — we say so honestly.
From joint replacement
Joint replacement is a "single-use" solution: revision after 15–20 years is more complex than the primary surgery. Regenerative treatment regenerates the patients own joint, can be repeated indefinitely, preserves proprioception and natural biomechanics.
From regular PRP
Regenerative treatment uses CGF (5–8× platelet concentration + fibrin matrix) + MFAT (stem cells) + ultrasound navigation. Regular PRP is only 2–3× concentration without matrix and without stem cells. Regenerative treatment efficacy is 3–4× higher.
From hyaluronic acid
Hyaluronic acid is a temporary "lubricant" (effect 6–12 months, no regeneration). regenerative treatment triggers genuine tissue regeneration — lifelong effect, the joint achieves full regeneration to its original state. A hyaluronate → regenerative treatment combination after 3 months is also possible.
From corticosteroids
Corticosteroids (Diprospan, Kenalog) provide rapid 2–4 week relief, but destroy cartilage with repeated injections, weaken tendons, cause local osteoporosis. FDA: not more than 3 injections per year. Regenerative treatment instead — restores tissues without side effects.
From arthroscopic lavage
Arthroscopy for arthrosis without mechanical blocks (Moseley, NEJM 2002) is no better than placebo. With concomitant meniscus tear — a combination is possible: arthroscopy + intraoperative regenerative treatment (accelerates healing by 40–60%).
Key numbers
Comparison FAQ
In complete ligament tears (ACL Grade III, Achilles rupture), cauda equina syndrome, progressive paresis, unstable fractures, stage IV osteoarthritis with axial deformity, tumors, and active infections. In these cases regenerative treatment can be used before or after surgery — but not instead of it. We assess each case honestly.
Regenerative treatment is a comprehensive protocol: CGF (5–8× platelet concentration, slow-release fibrin matrix) + MFAT (mesenchymal stem cells from adipose tissue) + ultrasound navigation. Standard PRP is only 2–3× concentration without matrix and stem cells.
Hyaluronate is a viscous fluid that temporarily improves joint "lubrication". It does not interact with cartilage and does not initiate regeneration. Within 6–12 months the body fully metabolizes it. Regenerative treatment acts at the cellular level — stimulates new cartilage synthesis, with effect that strengthens over time.
PRP is obtained via 1 centrifugation (5–10 minutes). CGF — via 4 sequential centrifugation programs at different speeds (8–15 minutes), yielding concentrate 5–8× denser than PRP + a fibrin matrix providing slow release of growth factors over 7–14 days. Efficacy 3–4× higher.
No. MFAT — mechanically processed adipose tissue with intact MSC niche (no enzymes, EU-approved). SVF — enzymatic processing. BMAC — bone marrow aspirate with mesenchymal and hematopoietic cells. Choice depends on diagnosis: cartilage — MFAT, bone — BMAC.
Short-term effective (2–4 weeks), but with repeated use destroy cartilage, weaken tendons, cause local osteoporosis. FDA: maximum 3 injections per year per joint. For chronic pain regenerative treatment is preferable — treats the cause, not the masked symptom.
Arthroscopic lavage for osteoarthritis (Moseley, NEJM 2002) was no better than placebo. regenerative treatment at stage II reduces pain by 70–85% and stimulates Effect on cartilage tissue. With concomitant meniscus tear — combination is possible: arthroscopy + intraoperative regenerative treatment.
Choice is determined by diagnosis, stage, and history: PRP — early arthrosis, tendinopathies; CGF — chronic tendinopathies, arthrosis II; MFAT — arthrosis II–III, complex tendinopathies, FBSS; BMAC — bone necrosis, fractures, severe arthrosis III. Decision is made by the physician after MRI and ultrasound.
Clinic and method matching — free of charge
Describe your case and attach your MRI report. We will identify clinics that use the relevant methods and forward your request to them. No obligation; we reply within two working days.
Send a request +49 160 5736643