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What is PRP
Platelet-Rich Plasma (PRP) — a concentrate of platelets from the patient's blood. Platelets contain growth factors in alpha-granules.
PRP Composition
Platelets (concentration 2-5 times higher than in blood). Growth factors: PDGF, TGF-beta, VEGF, EGF, IGF-1. Small number of leukocytes (depends on system). Blood plasma.
Mechanism of Action
Growth factors stimulate migration and proliferation of resident cells (chondrocytes, tenocytes, fibroblasts). Enhance collagen and proteoglycan synthesis. Anti-inflammatory effect.
Limitations
Works only when viable resident cells are present. With significant damage to native cells, there are insufficient cells to stimulate. Liquid form — rapidly resorbs (hours).
What are Stem Cells (MFAT)
MFAT — patented technology for obtaining microfragmented adipose tissue that preserves the stromal-vascular fraction (SVF) in natural extracellular matrix.
MFAT Composition
Mesenchymal stem cells (MSC) — multipotent: can differentiate into chondrocytes (cartilage), tenocytes (tendons), osteoblasts (bone), fibroblasts (ligaments). Pericytes — stem cells of the vascular wall, stabilize microcirculation. Extracellular matrix — natural scaffold, ensures survival and function of stem cells.
Mechanism of Action
Differentiation: MSC become cells of the needed type (chondrocytes in joint, tenocytes in tendon). Paracrine secretion: release dozens of bioactive molecules: anti-inflammatory (IL-10, PGE2, TGF-beta), neurotrophic (NGF, BDNF), angiogenic (VEGF), anti-fibrotic. Immunomodulation: suppress autoimmune inflammation.
Advantages over Bone Marrow
Adipose tissue contains 500-1000 times more MSC than bone marrow. Harvest is less traumatic (mini-lipoaspiration vs iliac crest puncture). MFAT preserves the niche — stem cells remain in natural matrix, which increases their survival and function.
CGF — Enhanced PRP
CGF (Concentrated Growth Factors) — next-generation PRP. Developed by Professor Sacco (Nice).
CGF Differences from PRP
Concentration: 10 times more growth factors than standard PRP. Fibrin scaffold: CGF is not liquid but gel/membrane. Retained in the injury site for weeks, providing prolonged release. Leukocytes: in optimal ratio — neutrophils for antimicrobial protection, macrophages for regeneration coordination.
Synergy of CGF + MFAT
CGF provides: signaling molecules (growth factors), scaffold for cell attachment, anti-inflammatory environment. MFAT provides: stem cells for differentiation, paracrine secretion, long-term regeneration. Together — complete regenerative system.
Comparative Table
| Parameter | PRP | CGF | MFAT |
|---|---|---|---|
| Source | Blood (10-20 ml) | Blood (20-40 ml) | Adipose Tissue (20-50 ml) |
| Stem Cells | No | No | Yes (MSC, pericytes) |
| Growth Factors | 2-5x from blood | 10x from blood | Paracrine secretion |
| Scaffold | No (liquid) | Yes (fibrin) | Yes (ECM of adipose tissue) |
| Duration of Action in Tissue | Hours | Weeks | Months |
| Cartilage Regeneration | Minimal | Stimulation | True (new chondrocytes) |
| Disc Regeneration | No | Partial | Yes (CGF + MFAT) |
| Evidence Base | Extensive (Level I-II) | Growing (Level II-III) | Growing (Level II-III) |
Clinic and method matching — free of charge
Describe your case and attach your MRI report. We will identify clinics that use the relevant methods and forward your request to them. No obligation; we reply within two working days.
Send a requestSafety of Stem Cells
Autologous material
MFAT uses the patient's own cells. No risk of rejection, allergies, or infection transmission. No laboratory cultivation (cell expansion) required—cells are used immediately after harvesting.
Clinical Experience
Over 30,000 MFAT procedures worldwide. Over 200 scientific publications. FDA approved (USA), CE approved (Europe).
No Oncogenic Risk
Adult mesenchymal stem cells (unlike embryonic cells) have no oncogenic potential. Numerous studies confirm safety.
Questions
Mesenchymal stem cells from the patient's adipose tissue (MFAT technology). They can differentiate into chondrocytes, tenocytes, and osteoblasts. Plus pericytes and extracellular matrix—a natural scaffold.
Autologous (patient's own) cells. The risk of rejection, allergy and infection transmission is minimal.
Adipose tissue contains 500-1000 times more MSC. Harvesting is less traumatic. MFAT preserves the stem cell niche (ECM), increasing cell survival and function.
It depends on the injury. Mild tendinopathies may benefit from PRP. Osteoarthritis, disc herniation, and significant injuries require stem cells. Regenerative treatment combines both components for maximum effect.